Non–Vitamin K Antagonist Oral Anticoagulants in Elderly (?85 years) Patients With Newly Diagnosed Atrial Fibrillation

ObjectiveTo investigate the influences of non–vitamin K antagonist oral anticoagulants (NOACs) on rates initiations (OACs) and outcomes among elderly patients with atrial fibrillation (AF).MethodsFrom January 1, 2009, to December 31, 2015, 33,539 newly-diagnosed AF older than 85 years old who survived more 180 days after diagnosis were studied. Temporal trends regarding OAC initiation incident analyzed. The 1-year risks ischemic stroke, intracranial hemorrhage, mortality diagnosed each year compared that 2009.ResultsInitiation OACs was newly in significantly increased from 9.5% 34.3%, mainly due introduction NOACs (from 0% 26.2%). Several clinical factors associated underuse, including chronic obstructive pulmonary disease, abnormal renal function, anemia, history bleeding. Compared 2009 (incidence rate, 5.55%/year), risk stroke decreased era 4.20%/year; adjusted hazard ratio [aHR], 0.748 2012; 4.39%/year, aHR, 0.789 2014; 2.75%/year; 0.513 2015; all P<.01, except for 2013, 4.80%/year [P=.07]). Also, lower 2012 while ICH remained unchanged.ConclusionInitiation following NOACs. A mortality, composite adverse events observed, which temporally increasing prescription OACs.